Intervertebral disc tissue consists mainly of water, collagen and proteoglycans. Since this tissue is avascular, it cannot bleed itself, so it obtains nutrients through diffusion from nearby blood vessels. It is known that any drug taken into the body accumulates in the intervertebral disc and synovial tissues. Some research; suggested evidence that various analgesics, especially non-steroidal anti-inflammatory drugs, may have negative effects on the production of proteoglycans and some gene/protein structures necessary to maintain hydration and elasticity of the discs. Additionally, long-term use of analgesics has been reported to inhibit the body`s natural healing process, potentially exacerbating disc degeneration. Some studies have provided evidence that some analgesics can be used to prevent disc degeneration due to their anti-inflammatory properties. This review aimed to evaluate the contribution of analgesic drugs frequently used in emergency and neurosurgery practice to intervertebral disc degeneration.