e-ISSN: 2148-0842
Spinal ve Periferik Sinir Cerrahisi Bülteni
TND-SPSCG
Spinal ve Periferik Sinir Cerrahisi Bülteni

Spinal ve Periferik Sinir Cerrahisi Bülteni

2024, Sayı 104, No, 1     (Sayfalar: 041-044)

The Role of Necroptosis in Intervertebral Disc Degeneration

Tamer TAMDOĞAN 1 ,Sevim ÖNDÜL 1

1 Giresun Üniversitesi Tıp Fakültesi, Beyin ve Sinir Cerrahisi Ana Bilim Dalı, Giresun, Türkiye

Görüntüleme: 108
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İndirme : 25

Targeting the signaling pathways associated with necroptosis in order to end, regress or regenerate intervertebral disc degeneration holds great promise in the treatment of disc degeneration. If research achieves this goal, Innovative pharmaceuticals that can modulate the necroptotic pathway may be invented and/or developed and perhaps in the future, new therapeutic modalities may be offered for individuals whose disc degeneration is due to necroptosis. This review aimed to provide a comprehensive overview of intervertebral disc degeneration associated with necroptosis and to contribute to the increasing scientific knowledge in the pharmacomolecular field.

Anahtar Kelimeler : Annulus fibrosus, Intervertebral disc degeneration, Necroptosis, Nucleus pulposus