e-ISSN: 2148-0842
Spinal ve Periferik Sinir Cerrahisi Bülteni
TND-SPSCG
Spinal ve Periferik Sinir Cerrahisi Bülteni

Spinal ve Periferik Sinir Cerrahisi Bülteni

2024, Sayı 104, No, 1     (Sayfalar: 038-040)

Relationship Between Cutibacterium acnes and Intervertebral Disc Degeneration

Mustafa DOĞAN 1

1 Namık Kemal Üniversitesi Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı, Tekirdağ, Türkiye

Görüntüleme: 110
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İndirme : 27

It is suggested in the literature that Cutibacterium acnes may cause degeneration of intervertebral disc tissue, possibly due to the mediation of signaling pathways associated with low-grade infection and inflammation. Studies have shown the presence of Cutibacterium acnes in degenerated discs. However, the exact mechanism and causality are still debated. In this review, we aimed to convey the conflicting information in the literature regarding this complex relationship by discussing the relationship between bacteria and disc degeneration and their potential consequences for treatment/protection against it.

Anahtar Kelimeler : Cutibacterium acnes, intervertebral disc degeneration, NLRP3, Propionibacterium acnes, TLR2/NF-κBp65 signaling pathway