e-ISSN: 2148-0842
Spinal ve Periferik Sinir Cerrahisi Bülteni
TND-SPSCG
Spinal ve Periferik Sinir Cerrahisi Bülteni

Spinal ve Periferik Sinir Cerrahisi Bülteni

2024, Sayı 104, No, 1     (Sayfalar: 028-031)

The Role of Ferroptosis in Intervertebral Disc Degeneration

Sevim ÖNDÜL 1 ,Tamer TAMDOĞAN 1

1 Giresun Üniversitesi Tıp Fakültesi, Beyin ve Sinir Cerrahisi Ana Bilim Dalı, Giresun, Türkiye

Görüntüleme: 117
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İndirme : 27

Examination of its pathophysiology points to a strong connection of intervertebral disc degeneration with ferroptosis, a regulated cell death that occurs through an iron-dependent mechanism and the accumulation of reactive oxygen species. Hemoglobin, an oligometalloprotein, consists of four iron-carrying heme molecules and a globin molecule consisting of two alpha-two beta polypeptide chains. Increased heme values, especially as a result of neovascularization in the herniated nucleus pulposus, can accelerate degeneration by inducing cytotoxicity and ferroptosis. This study aimed to focus on the role of ferroptosis in intervertebral disc degeneration.

Anahtar Kelimeler : Annulus fibrosus, Ferroptosis, Intervertebral disc degeneration, Nucleus pulposus