e-ISSN: 2148-0842
Spinal ve Periferik Sinir Cerrahisi Bülteni
TND-SPSCG
Spinal ve Periferik Sinir Cerrahisi Bülteni

Spinal ve Periferik Sinir Cerrahisi Bülteni

2024, Sayı 104, No, 1     (Sayfalar: 007-013)

Targeted Treatments for Intervertebral Disc Degeneration Due to Cell Senescence

Mehmet Ali TEPEBAŞILI 1 ,Mehmet Yiğit AKGÜN 1 ,Özkan ATEŞ 1

1 Koç Üniversitesi Tıp Fakültesi, Beyin ve Sinir Cerrahisi Ana Bilim Dalı, Türkiye

Görüntüleme: 129
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İndirme : 33

Intervertebral disc degeneration is defined as the progressive structural disorder of the intervertebral disc, which is one of the main causes of low back pain. Degeneration may develop as a result of cell senescence, which is affected by many factors such as inflammation, oxidative stress, mechanical stress, and genetics. Cell senescence is defined as the irreversible cessation of the cell cycle and the secretion of aging-related molecules. Elucidating this process is of great importance for developing treatment strategies targeting cell aging. The results of some treatments developed in recent years seem promising.

Anahtar Kelimeler : AMPK/GSK3β, Cellular senescence, Intervertebral disc degeneration, mTOR